Does Exercise STOP the Effect of Fasting

Click Here to Subscribe:
Website:



Get the Apparel I Wear at




Does Exercise STOP the Effect of Fasting - Thomas DeLauer



mTOR

mTOR responds to signals from nutrients, growth factors, and cellular energy status and controls cell growth and proliferation based on this (by regulating protein synthesis)

In other words, whenever we have an increase in nutrition (mainly protein) and calories we essentially tell the body that plentiful times are here - our cells increase their working capacity and ATP production is increased

Cells increase division and we are then primed for growth and repair - mTOR is the protein that senses this

It’s important to realize that mTOR is neither good nor bad, but too much or too little can have negative consequences

You see, mTOR increases energy production, but also creates more junk products

Autophagy is the process that degrades these junk products, but it is only usually active when mTOR is decreased

The Good & Bad of mTOR Activation

The Good

mTOR activation allows us to put on more muscle (and fat) and we
increase various hormones such as IGF-1

mTOR increases ATP production and creates new mitochondria - it also increases mitochondrial metabolism (by activating PGC1a)

The Bad

Too much mTOR activation, however, contributes to a large number of human diseases, including cancer, obesity, type 2 diabetes, depression and neurodegeneration

Balance

A study published in the journal Cell Metabolism found that too little mTOR activation can be equally as bad as too much

The study found (in rats) that too little mTOR activity actually harms the liver - mice were fed an excess calorie diet, but given rapamycin to induce autophagy

Researchers found that persistent suppression of mTORC1 activity in the liver leads to low-level inflammation that is enhanced by feeding a HFD

Hepatocytes bearing deficient mTORC1 activity are less competent to cope with oxidative stress and other inflammation-related insults

Note: HCC is the fifth most common cancer subtype worldwide, with a median survival of 6–16 months after diagnosis

Persistent elevation of hepatic mTORC1 activity in the setting of overnutrition and obesity, or conversely, protracted suppression of mTORC1 activity induced by rapamycin and related drugs, sets in motion a spiraling sequence of pathologic events that promotes HCC.

Autophagy

The opposite side of the mTOR coin is the repair and recycling system - it’s activated with the mTOR switch is turned off

And, as we know, the main process that carries out repair and recycling in our cells is called autophagy

Autophagy is the mechanism our cells use to recycle damaged proteins and cell machinery (including mitochondria) and use their parts to make new machinery and new sources of energy - recycling old cellular machinery helps protect a cell from premature aging

Autophagy allows your cells to recycle used material for use as energy during stresses such as fasting, instead of breaking down valuable things such as muscle - preventing catabolism (breaking down) of muscle is always a good thing

Autophagy occurs at a low basal level in virtually all cells, being important in protein and organelle turnover - however, it may be up-regulated in times of need

When mTOR goes up, it shuts down autophagy - mTOR is sensitive to dietary amino acids (protein)

Fasting & Working Out

Journal - Autophagy

Fasting increase autophagy (as does caloric restriction and certain foods; EGCG, ginger, curcumin, etc.)



Explains that resistance training activates mTOR (as does protein, excess calories, IL-6, testosterone, etc.)



References

1) Jung CH , et al. (n.d.). mTOR regulation of autophagy. - PubMed - NCBI. Retrieved from
2) mTOR Pathways in Cancer and Autophagy. (n.d.). Retrieved from
3) Glick D , et al. (n.d.). Autophagy: cellular and molecular mechanisms. - PubMed - NCBI. Retrieved from
4) Autophagy fights disease through cellular self-digestion. (28, February). Retrieved from
5) Autophagy fights disease through cellular self-digestion. (28, February). Retrieved from
6) Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle. (n.d.). Retrieved from
7) Short-term fasting induces profound neuronal autophagy. (16, August). Retrieved from

intermittent fasting,fasting and autophagy,autophagy,mtor,working out and mtor,mtor vs autophagy,mtor autophagy pathway,mtor and autophagy,working out and fasting,working out vs fasting,mtor benefits,autophagy benefits,what is mtor,what is autophagy,fasting and workout,should you workout while fasting,fasting and mtor,mtor and ampk,mtor and muscle growth,mtor and cancer,mtor and longevity,autophagy and longevity,thomas delauer,keto,fasting,weight loss,